Charlton will be hoping to return to The Valley and take all three points on Sunday afternoon when they welcome Preston North End to south-east London (12pm).
Bowyer's boys picked up a hard-earned point against table-toppers West Bromwich Albion last weekend and, with Preston currently sat in second, it is likely to be another tough test for the Addicks.
But Charlton are in confident mood and will be looking for a repeat of their fine performance against Derby County last time out in SE7 which earned them a 3-0 win.
Preston look to have more than improved on last seasons 14th-place finish in the Championship. They currently sit two points behind first-placed West Brom and come to The Valley off the back of two victories, one defeat and three draws in their last six games.
Alex Neil will be hoping that last week's late comeback win again Blackburn Rovers can spur them on when they travel to the capital on Sunday morning.
Bowyer will continue to be without the option of Lyle Taylor for the visit of Preston after it was revealed that the forward had suffered a small setback in his recovery.
Elsewhere, Jonny Williams, Sam Field and Tomer Hemed all remain sidelined, as does Lewis Page, while Ben Amos continues to recuperate following minor finger surgery. The game will also come too soon for George Lapslie and Adam Matthews.
For Preston, centre-half Ben Davies looks set to get back into the squad having missed last weekend's win over Blackburn. In midfield, Josh Harrop is unlikely to feature having picked up an injury to his hamstring.
The Lilywhites are also without captain Tom Clarke, while Louis Moult remains out for the season.
Meanwhile, The Valley will welcome back Wembley hero Patrick Bauer, who is sure to get a good reception from all four sides of the ground.
Charlton boss Lee Bowyer: “They’re a good side. The manager has done a good job there and he’s made sure that they have become a good Championship side. They’re sitting in second and deservedly so. Every point in this division, you have to earn."
Preston Defender and former Charlton player, Patrick Bauer: "I know from my time there that the togetherness is very good so, for me, it is not a surprise to see Charlton doing well. I’m here at Preston now and my aim is to be successful."
Charlton have faced Preston 72 times, winning on 24 occasions, drawing 14 and losing 34.
The last time that the Addicks beat Preston was at The Valley back in 2011 when Charlton hit five against the Lilywhites on their journey to the League One title.
Goals from Johnnie Jackson, Michael Morrison, Bradley Wright-Phillips and Danny Hollands ensured that Preston's late resurgence was too little, too late as Chris Powell's men earned a 5-2 win.
David Webb will be the referee on Sunday. He has overseen 10 games this season dishing out 25 yellow cards and no reds, awarding three penalties along the way.
Webb last refereed a Charlton game back in January during the Addicks' 0-0 stalemate against Peterborough United in League One.
He will be joined by Graham Kane and Adrian Waters as his assistants. Craig Hicks will be the Fourth Official.
Supporters purchasing concession tickets should be aware that ID checks will be in place for those who may appear close to, or outside, the relevant age groups. Appropriate identification includes a driving license, passport or any other photographic ID that shows date of birth. The club will also accept a copy/photograph of these documents provided the date of birth is clearly legible.
Supporters are advised to get to the ground early to avoid queuing to get into the ground. Supporters are also asked to not bring bags, if possible, to help speed up the bag search process.
A 'print at home' option is available, or tickets can be scanned from mobile devices. Tickets are available from the stadium on the day, but supporters should note that a £3 increase on adult, over 65s and U21 tickets kick in 2 hours before kick off. This does not affect an U11 ticket which will remain at £1.
Supporters can follow all the build-up to the game on Charlton's official Instagram account, official Twitter account and Facebook page.
Supporters who live abroad will be able to watch live coverage of the match on Valley Pass for a one-off price of £5 or £110 for the season.
Meanwhile, the game will be broadcast on Sky Sports Main Event and Sky Sports Football.